Two-stage randomized trials: outstanding issues
نویسندگان
چکیده
منابع مشابه
Randomized Phase II Trials: a Bayesian Two-Stage Design
Single-arm two-stage designs are commonly used in phase II of clinical trials. However, the use of randomization in phase II trials is currently increasing. We propose a randomized version of a Bayesian two-stage design due to Tan and Machin [2]. The idea is to select the two-stage sample sizes by ensuring a large posterior probability that the true response rate of the experimental treatment e...
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ژورنال
عنوان ژورنال: Statistics in Medicine
سال: 2012
ISSN: 0277-6715
DOI: 10.1002/sim.5342